Isaac Guerendo

As we head into the 2025 fantasy football season, Isaac Guerendo is a name that should be on every fantasy owner's radar, particularly those invested in the San Francisco 49ers' backfield. Guerendo, a fourth-round pick in the 2024 NFL Draft, has suddenly found himself in a prime position due to offseason moves and the injury history of the team's starter, Christian McCaffrey. With Jordan Mason now with the Vikings and Elijah Mitchell traded to the Kansas City Chiefs, Guerendo has ascended to the RB2 role for the 49ers.

Guerendo's value is heavily tied to the health of Christian McCaffrey, who has a history of injuries. In 2024, Guerendo took advantage of his opportunities when injuries struck, showcasing his potential with a 5.0 yards per carry average. This performance indicates that he is more than just a backup; he is a solid handcuff option with significant upside should McCaffrey go down. Given McCaffrey's age and injury history, it's not a matter of if Guerendo will see significant playing time, but when.

Physically, Guerendo is an impressive specimen. At 6 feet and 221 pounds, he combines size with speed, having run a 4.33 40-yard dash. This blend of power and speed makes him an excellent candidate for short yardage and goal-line situations, which could help reduce the wear and tear on McCaffrey. Additionally, Guerendo has demonstrated good hands and pass protection skills, making him a versatile back who can contribute in multiple facets of the game.

For fantasy owners, Guerendo is worth considering, especially in deeper leagues or as a late-round draft pick. He is expected to start getting picked in Round 8 of fantasy drafts, reflecting his potential to become a starter in the near future. With McCaffrey's age and injury history, Guerendo's role could expand significantly, making him a valuable asset for any fantasy team looking for a breakout running back.

Updated 06/28/2025