San Francisco 49ers

As the 2025 fantasy football season approaches, the San Francisco 49ers are undergoing significant changes following a disappointing 6-11 season in 2024. The team has focused on a youth-driven rebuild, trading away key players like Deebo Samuel to Washington and bolstering their defense with draft picks like DE Mykel Williams, DT Alfred Collins, and LB Nick Martin. Despite these changes, the 49ers' faithful can still expect a fantasy-friendly offense led by head coach Kyle Shanahan, whose system emphasizes efficiency and a strong running game.

Brock Purdy has secured a five-year, $265 million contract extension, solidifying his role as the starting quarterback. However, his fantasy potential is somewhat tempered by a receiving corps that is more injury-prone than in previous years. Despite this, Purdy remains a reliable option for fantasy managers, particularly in two-QB and best ball leagues due to his consistent floor and the 49ers' favorable schedule in 2025. The loss of Deebo Samuel and the anticipated absence of Brandon Aiyuk for part of the season mean that other receivers will need to step up, with Ricky Pearsall emerging as a potential sleeper pick if he can stay healthy.

Christian McCaffrey continues to be a pivotal figure in the 49ers' offense, though his health remains a major concern. After playing only four games last season, McCaffrey's boom-or-bust potential makes him a high-risk, high-reward fantasy pick. If he can stay healthy, his ceiling is among the highest in the league, but limited exposure might be wise due to his recent injury history. Isaac Guerendo and rookie Jordan James are advisable late-round handcuffs for fantasy managers who invest in McCaffrey.

The 49ers' defense, bolstered by new additions and the return of Defensive Coordinator Robert Saleh, aims to improve upon last year's performance. With a projected win total of 10 games, the team is set for a significant turnaround from their 2024 season. Fantasy managers can still rely on George Kittle at tight end, and Jauan Jennings may emerge as the top wide receiver option early in the season. Overall, while the 49ers face challenges, their system and some key players provide solid fantasy value for those who know where to look.

Updated 08/23/2025